Recently, Boston University School of Medicine (BUSM) researchers found a new gene with post-traumatic stress disorder (PTSD) is closely related. The study was published in Molecular Psychiatry journal, the study showed that this newly discovered gene can protect brain cells by stress and other devastating effects of the gene may be involved in the occurrence of PTSD.
The article is a post-traumatic stress disorder genome-wide association study (GWAS) has important research study reveals the changes of retinoic acid-related orphan receptor alpha gene (RORA) associated with the occurrence of PTSD development. BUSM and Boston, Virginia Medical Systems clinical research psychologist Dr. Mark W. Miller, associate professor of the National PTSD Center is the main leader of the study.
Post-traumatic stress disorder in encounter or confrontation significant pressure, disorders of psychological state sequelae. These experiences include life threatened, serious physical injury, physical or spiritual stress. Sometimes called post-traumatic stress reactions (post-traumatic stress reaction) to emphasize that this phenomenon is to experience post-traumatic reasonable results, rather than the patients' state of mind is inherently problem.
Previous genome-wide association study with other psychiatric disorders, including attention deficit hyperactivity disorder, bipolar disorder, autism and depression related RORA gene. Such as post-traumatic stress disorder, all of these symptoms of these diseases have been associated with changes in brain function, RORA of one of the main functions is to protect brain cells from the destructive effects of oxidative stress, hypoxia and inflammation.
The study participants were about 500 male and female veterans and their intimate partners, all experienced trauma, about half of them had PTSD. Each participant DNA extracted from blood samples by a doctor. About 1.5 million genetic markers in DNA analysis checks associated with PTSD, and reveal the the RORA gene variant (rs8042149) with a high degree of correlation with PTSD. These results suggest that the, RORA risk variants are more likely to suffer of PTSD.