The macaque is the next of kin, is also the most widely used in the study of non-human primate model animals. Although the macaque in biology and medicine has been a very long time, but very limited understanding of the macaque genome sequence polymorphisms.
Bing Su Laboratory of Kunming Institute of Zoology, Chinese Academy of Sciences (PhD Zhang Yanfeng, etc.) and the Genomics Institute of the cooperation, the use of second-generation sequencing methods, the Chinese macaque whole-genome sequence analysis. Sequencing depth of the macaque genome coverage of 11.56 times. Macaque genome sequence of measured and foreign India, they found a total of 5.5 million single nucleotide sequence polymorphism (SNP), of which 2.94 million SNPs heterozygous polymorphism in the Chinese macaque genome 2.56 million SNPs is the difference between Chinese macaques and Indian macaques. At the same time, they also found more than 120,000 of the genome structural variation (Structural variation, SV).
This work is the first macaque genome sequence polymorphisms analytical mass sequence polymorphism data reported for rhesus monkeys biology and pre-clinical medical research database of great value. The research results were published the well-known publication of the genome "Genome Biology" (Genome Biology).